top of page

ST. JOHN 17 EPISTLE





    The epistle is taken from the book of Saint John, the Divine, chapter 17. The Gospel. The Gospel bells are ringing, over land from sea to sea. Blessed news of free salvation, Fari offers you and me. The Gospel trumpet sound, the news of Zion grace. We happy souls draw near, and behold King Rasta's face. The year of Jubilee has come. Return your ransoms to your home.

    The Epistle:These words spake Jesus and lifted up his eyes to heaven and said, Father, the hour has come. Glorify thy son, that thy son will also glorify thee. As thou hast given him power over all flesh, that he will give eternal life to as many as thou hast given him. And this is life eternal, that we will know thee. The only true God, and Jesus Christus whom Thou hast sent.I have glorified Thee on the earth. I have finished the work which Thou gavest me to do. And now, O Father, glorify Thou me with Thine own self, with the glory which I had with Thee before the world was.I have manifested Thy name unto the men which Thou gavest me out of the world. Thine they were, and Thou gavest them me, and they have kept Thy word. Now they have known that all things whatsoever Thou hast given me are of Thee. For I have given unto them the words which Thou gavest me, and they have received them, and have known surely that I came out from Thee, and they have believed that Thou didst send me.I pray for them, I pray not for the world, yet for them which Thou hast given me. For they are Thine, and all mine are Thine, and Thine are mine, and I am glorified in them. And now I am no more in the world. Yet these are in the world, and I come to Thee. Holy Father, keep through Thine own name those whom Thou hast given me, that they will be one, as we are.While I was with them in the world, I kept them in Thy name. Those that Thou gavest me I have kept, and none of them is lost, yet the son of perdition, that the Scriptures be fulfilled. And now come I to Thee, and these things speak I in the world, that they will have my joy fulfilled within themselves. I have given them thy word, and the world hath hated them, because they are not of the world, even as I am not of the world.I pray not that thou shouldst take them out of the world, yet that thou shouldst keep them from the evil. They are not of the world, even as I am not of the world. Sanctify them through thy truth, for thy word is true. As Thou hast sent me into the world, even so have I also sent them into the world. And for their sakes I sanctify myself, that they also will be sanctified through the truth.Neither pray I for these alone, yet for them also which will believe on me through their word. That they all will be one, as Thou, Father, art in me and I in Thee. That they also will be one in us. That the world will believe that Thou hast sent me.And the glory which thou gavest me, I have given them, that they will be one, even as we are one. I in them, and thou in me, that they will be made perfect in one, and that the world will know that thou hast sent me, and hast loved them as thou hast loved me.Father, I will that they also, whom thou hast given me, be with me where I am, that they will behold my glory which thou hast given me, for thou lovest me before the foundations of the world.O Righteous Father, the world hath not known Thee, yet I have known me, and these have known that Thou hast sent me. And I have declared unto them Thy name, and will declare it, that the love wherewith Thou hast loved me will be in them, and I in them. A Man, Selah.Will the meditation of our hearts and the words of our mouth, be acceptable in thy sight, O Jah, our strength and our Redeemer, who liveth and reigneth forever. Selah. 



    Jack Kruse’s 30 Levee's for Wellness


      Dr. Jack Kruse’s 30 Levee's for Holistic Wellness

      Levee 1: Current Cellular Homeostasis Determines Cellular Fates

      • Cellular health influences future cell fate.

      • "Cellular homeostasis" reflects the balance of cellular conditions.

      • Redox potential is a key factor, indicating cell vitality.

      • Mitochondria convert sunlight and water into energy.

      • Longevity theory focuses on environmental impact rather than just disease.

      • The concept of cellular terroir emphasizes how surroundings affect cell health.

      • Understanding this relationship can improve health and extend lifespan.

      Levee 2: Leptin Sensitivity and Resistance Determine Energy Balance

      • Leptin manages energy balance and metabolism.

      • Produced by fat cells, it communicates with the hypothalamus to regulate energy.

      • Leptin receptors are primarily located in the lateral hypothalamus.

      • Leptin impacts hormonal balance, fertility, and cell growth.

      • Human cells use mitochondria to generate energy from oxygen, a process evolved for complexity.

      • Quantum biology may enhance energy generation.

      • Disruptions in leptin function can lead to obesity and related health issues.

      Levee 3: Cellular Inflammation is Critical

      • Inflammation acts like a fire; if unchecked, it can cause severe damage.

      • It’s linked to obesity, age-related diseases, and cell death.

      • Understanding inflammation pathways can help identify health solutions.

      Levee 4: Dietary Principles of Longevity

      • Energy metabolism is essential; diet directly impacts health and lifespan.

      • Key dietary principles include:

        • Limiting inflammation.

        • Reducing omega-6 fatty acids.

        • Minimizing fructose and carbohydrates.

        • Emphasizing omega-3-rich protein sources.

        • Avoiding nutrient-depleting foods.

      • Discusses Epi-Paleolithic eating and the role of micronutrients and macronutrients.

      Levee 5: The Brain-Gut Axis is Critical to Organizational Health

      • The brain-gut relationship is vital for nutrient management and energy levels.

      • The vagus nerve connects gut and brain, providing essential feedback.

      • Disruptions can lead to health issues, including neurological diseases and digestive disorders.

      • A healthy brain-gut connection is crucial for overall health.

      Levee 6: Immunity Affects Regulation

      • Immunity is the body's defense system, comprising cell-mediated and humoral immunity.

      • Autoimmune diseases arise when the immune system attacks healthy tissues.

      • Factors affecting immune balance include:

        • Ineffective brain-gut axis

        • Graft versus host disease

        • Molecular mimicry

        • Low vitamin D levels

        • Failures in the complement system.

      Levee 7: ROS Generation

      • Reactive Oxygen Species (ROS) are byproducts of energy production in mitochondria.

      • While they can cause cellular damage, they also play roles in signaling and repair.

      • Managing ROS levels is crucial for cell health and longevity.

      • Coenzyme Q10 (CoQ10) is vital for energy production and may need supplementation when levels drop.

      Levee 8: Understanding Advanced Lipoxidation End-Products (ALEs)

      • ALEs are harmful proteins formed from certain nutrient consumption.

      • They are more concerning than AGEs, contributing to oxidative stress.

      • MDA, a byproduct, indicates cellular stress and can lead to mutations.

      • Imbalanced omega fatty acids can cause health issues, including joint diseases and osteoporosis.

      Levee 9: Understanding Advanced Glycation End-Products (AGEs)

      • AGEs form when sugars bind to proteins or fats, leading to various diseases.

      • They activate the RAGE receptor, causing inflammation through NF-kappaB activation.

      • High sugar intake worsens damage, leading to chronic health issues.

      • Managing AGE levels is crucial for preventing conditions like diabetic neuropathy and Alzheimer’s.

      Levee 10: Mitochondrial Signaling and Its Role in Health

      • Mitochondrial signaling affects cell functions and health outcomes.

      • Retrograde signaling influences stress responses and cancer development.

      • Anterograde signaling promotes mitochondrial biogenesis and telomere maintenance.

      • Proper mitochondrial function is essential for energy production and longevity.


      Levee 11: The mTOR Pathway—Key to Life and Health

      • mTOR (mammalian target of rapamycin) is a critical signaling pathway that influences health and disease.

      • Activation Factors:

        • Amino acids

        • Insulin

        • Growth factors

      • Impairment: Nutrient or energy deficiencies can reduce mTOR activity.

      • Key Functions:

        • Protein Synthesis: Regulates the production of proteins.

        • Ribosome Production: Facilitates the creation of ribosomes for protein synthesis.

        • Cancer Link: mTOR pathway supports growth in cancer cells; interacts with the PI3K-AKT pathway.

      • Research Focus: Targeting mTOR for therapies, identifying biomarkers for treatment suitability, and exploring natural compounds (e.g., curcumin, cacao, EGCG) that affect mTOR.

      Levee 12: PPAR Gamma—The Key Regulator of Metabolism

      • PPAR gamma (peroxisome proliferator-activated receptor gamma) is a key regulator of fat cell metabolism.

      • Types of PPARs:

        • Alpha: Involved in fat burning.

        • Delta: Regulates metabolism and energy homeostasis.

        • Gamma: Controls lipid storage and glucose metabolism.

      • "Confluent Gate": Acts as a central pathway for metabolism, influencing gene expression through epigenetic mechanisms.

      • Activation: Influenced by free fatty acids and specific endogenous ligands like PGJ2 (prostaglandin).

      • Role of DHA: An omega-3 fatty acid that activates PPAR gamma, promoting metabolic health.

      Levee 13: Defective Signaling Responses

      • Cellular Homeostasis: Relies on effective communication among cellular systems.

      • Leptin's Role: Essential for appetite regulation; resistance to leptin can disrupt biological processes and lead to disease.

      • Metaphor: Signaling failures likened to an orchestra lacking a conductor, resulting in chaos (e.g., cancer).

      • Health Issues from Poor Signaling: Can lead to cell death, aging, diabetes, neurodegenerative diseases, and cancer.

      • Importance of Maintenance: Enhancing cellular signaling systems is crucial for long-term health.

      Levee 14: Rapid Epigenetic Modifications

      • Immediate Changes: Diet, hormones, and environmental factors can quickly influence gene activity.

      • Mind-Body Connection: Thoughts can activate DNA; hormonal changes affect gene expression and protein production in nanoseconds.

      • NF-kappa B Role: Key in epigenetic modifications; further exploration is needed for its inhibition.

      • Complexity of Evolution: Rapid molecular changes do not necessarily alter overall traits, reflecting life's intricacies.

      Levee 15: Autophagy

      • Autophagy is the process of breaking down and recycling cell components, crucial for cellular health.

      • Significance in Heart Disease: Understanding autophagy can help address heart cell death and related risks.

      • Types of Autophagy:

        • Microautophagy: Targets smaller cell components.

        • Chaperone-Mediated Autophagy (CMA): Selectively breaks down specific proteins.

      • mTOR Influence: The mTOR pathway heavily regulates autophagy, impacting heart health.

      • Public Health Relevance: Insights into autophagy could lead to strategies for preventing heart disease.

      Levee 16: Oncogenesis

      • Oncogenesis is the transformation of normal cells into cancerous ones.

      • Environmental Influence: Rising cancer rates over 125 years linked to changes in environment and lifestyle.

      • Focus on Prevention: Emphasis on preventing cancer through managing cellular environments rather than solely curing it.

      • Health Practices: Consistent adoption of healthy practices can significantly reduce cancer risk.

      • Dietary Changes: Shifts toward grain-based diets and away from nutrient-dense foods may contribute to cancer rates.

      • Oxidative Stress: Chronic oxidative stress from dietary changes and environmental factors increases disease risks.


      Levee 17: Understanding Stem Cell Reserves

      • Stem Cells' Role: Essential for replacing damaged or aged cells, but their reserves are limited.

      • Timing and Context: Neglecting health early in life may lead to faster depletion of stem cell reserves, impacting longevity.

      • Future Possibilities: Potential for creating pluripotent stem cells to replenish reserves and enhance lifespan.

      • Protective Strategies: Importance of safeguarding stem cells through healthy lifestyle choices from an early age.


      Levee 18 - Understanding Sirtuins and Their Role in Cell Health

      • Sirtuins are proteins that help regulate cellular health and longevity, often referred to as the "guardians of the cell."

      • Role in Aging: Sirtuins rejuvenate cells, repair DNA, and increase antioxidant production.

      • Caloric Restriction: Sirtuins play a critical role in extending lifespan through the IGF axis and telomere lengthening.

      • Sources of Boosters: Resveratrol and quercetin from foods (e.g., red wine, grapes, dark chocolate) may activate sirtuins.

      • Overall Impact: Supporting sirtuin activity is vital for managing stress and promoting healthy aging.


      Levee 19 - Apoptosis

      • Programmed cell death that maintains healthy tissues by eliminating unnecessary or damaged cells.

      • Key Changes:

        • Blebbing: Bulging of the cell membrane.

        • Loss of Membrane Asymmetry: Altered cell membrane structure.

        • Cell Shrinkage: Reduction in cell size.

        • Nuclear Fragmentation: Breakdown of the cell's nucleus.

        • Chromatin Condensation: Tight packing of genetic material.

        • DNA Fragmentation: DNA broken into smaller pieces.

      • Importance: Essential for normal development and tissue homeostasis; excessive apoptosis can lead to atrophy, while insufficient apoptosis can contribute to cancer.

      • Regulation:

        • Extracellular Signals: Toxins, growth factors, nitric oxide, cytokines, hormones.

        • Intracellular Signals: Glucocorticoids, heat, radiation, nutrient depletion, viral infection, hypoxia.

      • Mechanism: Signals activate regulatory proteins, allowing cells to either proceed to apoptosis or survive.

      Levee 20 - Supply Side Stability

      • Maintaining cell health and function as organisms age, crucial for longevity.

      • Role of P53:

        • Protects genetic material by halting the cell cycle in somatic cells, preventing cancer.

        • Regulates the supply of stem cells in organs, including the mammalian brain.

      • Aging Connection:

        • As stem cell availability declines with age, maintaining a vibrant supply and potentially reversing aging in somatic cells is vital for longevity.


      Levee 21 - Adaptogens

      • Natural plant-derived substances that restore balance to neuroendocrine and immune systems under stress.

      • Common in traditional medicine (e.g., Chinese medicine, Ayurveda).

      • Common Adaptogens: Licorice, maca, rhodiola, resveratrol, quercetin, ginseng, holy basil, astragalus.

      • Astragalus and Telomeres: Extracts like TA-65 are developed to potentially lengthen telomeres, impacting aging.

      • Future Significance: Increasing research on adaptogens’ health benefits and potential role in longevity.

      Levee 22 - Cellular Depletions

      • Overview: Cellular damage and aging result from nutrient and cofactor depletion, affecting cellular function.

      • Impact of Dialysis: Higher risk of heart disease due to removal of water-soluble proteins, including B vitamins.

      • Medication Effects: Chronic use of medications (e.g., Coumadin) depletes essential vitamins, leading to health issues like osteoporosis.

      • Dietary Impacts: High glucose/fructose intake increases demand for vitamin B6 and magnesium, leading to complications in diabetic patients.

      • Magnesium Deficiency: Linked to restless leg syndrome and exacerbated by certain medications.

      • HIV Medications: Can deplete zinc, affecting testosterone production and wound healing.

      Levee 23 - Unintended Consequences of Medical Interventions

      • Overview: Negative outcomes from medical interventions; 100,000 deaths per year from medical errors may be underestimated.

      • Example of Mammography: While common, it exposes patients to X-rays, raising long-term cancer risks.

      • Emerging Technologies: Thermography as an alternative to mammography for detecting early tumors.

      • Scope: Examination of unintended consequences across various medical specialties.

      Levee 24 - Understanding DNA and RNA Changes

      • Human Genome Project: Enabled mapping of the complete human genome, allowing study of DNA and mRNA changes.

      • Importance of mRNA: Carries genetic instructions to produce proteins that influence health and disease.

      • Research Focus: Analyzing genome changes associated with diseases and understanding gene interactions.

      • Real-World Example: Lipodystrophy in HIV patients linked to mitochondrial DNA depletion; growth hormone therapy helps restore body composition .

      Levee 25 - Understanding Hypoxia

      • Definition: Insufficient oxygen supply to tissues, leading to cellular issues.

      • Body's Response: Cells use apoptosis and autophagy to cope with challenges.

      • Impact of Aging: Decreased blood flow and oxygen levels impair repair signaling, leading to organ failure and diseases.

      • Connection to Conditions: Contributes to heart disease and sleep disorders like sleep apnea, affecting overall health.

      Levee 26 - Understanding Organizational Failures in Our Body

      • Overview: Explores how organs and tissues fail as we age and strategies to mitigate issues.

      • Types of Failure: Sudden (acute) vs. gradual (chronic) organ failure; bone fractures vs. osteoporosis.

      • Brain Health: Linked to autophagy and influenced by gut health; cognitive decline can result from other organ failures.

      Levee 27 - Understanding Heat Shock Proteins (HSP)

      • Definition: HSPs are proteins produced by cells in response to stressors (e.g., temperature increase, injuries).

      • Function:

        • Assist in proper protein folding, ensuring correct structure for functionality.

        • Help maintain cellular homeostasis.

        • Involved in transporting proteins across cell membranes and regulating steroid receptors.

      • Key Protein: Ubiquitin marks damaged proteins for breakdown, supporting cell health.

      • Stress Response: Activated by various stressors, including infections, inflammation, and physical exercise.

      • Aging Connection: Decline in protein folding ability with age linked to diseases (e.g., Alzheimer’s, Parkinson’s).

      • Research Implications: Understanding HSPs may lead to new approaches for age-related diseases and support healthier aging.

      Levee 28 - The Mystery of Sleep

      • Sleep's Importance: Although we spend a third of our lives sleeping, its exact purpose remains unclear.

      • Repair and Maintenance: Sleep is crucial for bodily and brain repair, regulating energy metabolism via the hypothalamus.

      • Cognitive Effects: Sleep deprivation leads to cognitive decline and impaired learning.

      • Sleep Apnea: Linked to obesity and can be life-threatening, emphasizing the sleep-energy metabolism connection.

      • Longevity Correlation: Sleeping less than 5.5 hours or more than 9 hours is associated with shorter lifespans.

      • Complex Relationship: Sleep is intricately linked to health; exploring its connection to obesity is essential.

      • Autophagy Role: Sleep aids in clearing damaged proteins, maintaining cellular health through processes like ubiquitination.

      Levee 29 - Hormesis: The Power of Low-Dose Stress

      • Hormesis Concept: Low-dose exposure to stressors can trigger positive biological responses.

      • Exercise Analogy: Like exercise, mild stress can enhance health and lifespan; excess stress can be harmful.

      • Observed Benefits: Mild stress can improve cellular resilience and organ function (e.g., cardiac output).

      • Beneficial Compounds: Certain spices (e.g., curcumin, ginger) and plant polyphenols (e.g., resveratrol) exhibit hormetic effects.

      • Health Implications: Understanding hormesis could reveal how controlled stress exposure promotes longevity and health.

      Levee 30 - Geopathic Stress and Quantum Biology: The Hidden Forces Affecting Health

      • Geopathic Stress Definition: Natural forces affecting health, influenced by factors like magnetic field variations.

      • Examples: Electric power grids, EMFs from cell phones, and areas with mold or lichen growth.

      • Animal Navigation: Birds utilize geopathic stressors for migration, highlighting the biological significance.

      • Quantum Biology Exploration: Investigates how subatomic particles and fields affect biological processes.

      • Non-Locality Concept: Suggests that distant forces may impact cellular function, linking environmental factors to health.

      • Research Frontier: Understanding geopathic stress and quantum biology could reveal new insights into health and disease.



      bottom of page